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Selection pressure on prevalence of a dominant mutation

Suppose we have a dominant mutation in the population with some prevalence . That means that a fraction of the alleles at that locus in the population are our mutation, while the rest are wild-type. We’d like to know how that prevalence changes over time. Some of those changes will be random, but we can …

Variant fixation probability

Introduction What happens to a new mutation? Every person has some new mutations in their somatic genome, mostly caused by errors in DNA replication. They can pass that mutation on to their descendants. We know of a couple of historical mutations that look like they are all from a single common ancestor – for example, …